Dimethylformamide diethylacetal → HCID 178474251, compound

HRID 1602259Notes

Reaction equation

HRID 1602259 reaction equation
[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:16]([C:17]#[N:18])=[C:15]([NH2:19])[NH:14][N:13]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].C(O[CH:23](OCC)[N:24]([CH3:26])[CH3:25])C>C1(C)C=CC=CC=1>[C:1]([NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH:11][C:12]2[C:16]([C:17]#[N:18])=[C:15]([N:19]=[CH:23][N:24]([CH3:26])[CH3:25])[NH:14][N:13]=2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 19610610HCID 19610610, compound

Product 1

HCID 178474251HCID 178474251, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of 5.3 g (20.7 mmol) of 3-(4-acetylamino-phenylamino)-5-amino-4-cyano-pyrazole in 4.4 ml (24.9 mmol) of N,N-dimethylformamide diethyl acetal (97%) and 100 ml of toluene is heated under reflux for 4 hours. The reaction mixture is then cooled to room temperature and filtered and the filter residue is washed with toluene, yielding the title compound having a water content of 4.22%; m.p. 275-276° C. (decomp.).

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 4 hours
  3. filtrationfiltered
  4. washthe filter residue is washed with toluene

Sources & evidence

ORD record
ord-fbbece73f05b4a71bb0a38d6b0b3b7a3
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

Loading…