Dimethylformamide diethylacetal → HCID 178484266, compound

HRID 1602262Notes

Reaction equation

HRID 1602262 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([NH:7][C:8]2[CH:13]=[CH:12][C:11]([N:14]([CH3:16])[CH3:15])=[CH:10][CH:9]=2)[C:3]=1[C:17]#[N:18].C(O[CH:22](OCC)[N:23]([CH3:25])[CH3:24])C>C1(C)C=CC=CC=1>[C:17]([C:3]1[C:4]([NH:7][C:8]2[CH:9]=[CH:10][C:11]([N:14]([CH3:15])[CH3:16])=[CH:12][CH:13]=2)=[N:5][NH:6][C:2]=1[N:1]=[CH:22][N:23]([CH3:25])[CH3:24])#[N:18]

Participants

4

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 15687201HCID 15687201, compound

Product 1

HCID 178484266HCID 178484266, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
30 °C

Procedure

A suspension of 10 g (41.3 mmol) of 5-amino-4-cyano-3-(4-dimethylamino-phenylamino)-pyrazole [for preparation see: Arch.Pharm.(Weinheim) 326, 245 (1993)] in 8.75 ml (49.5 mmol) of N,N-dimethylformamide diethyl acetal (97%) and 200 ml of toluene is heated under reflux for 1 hour. The reaction mixture is then cooled to approx. 30° C. and filtered and the filter residue is washed with toluene, yielding the title compound; m.p. 281-282° C. (decomp.).

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 1 hour
  3. filtrationfiltered
  4. washthe filter residue is washed with toluene

Sources & evidence

ORD record
ord-5084f8fec3344cabbd648dea0e6dae8a
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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