Dimethylformamide diethylacetal → HCID 178425529, compound

HRID 1602271Notes

Reaction equation

HRID 1602271 reaction equation
[NH2:1][C:2]1[NH:6][N:5]=[C:4]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=2)[C:3]=1[C:15]#[N:16].C(O[CH:20](OCC)[N:21]([CH3:23])[CH3:22])C>C1(C)C=CC=CC=1>[C:15]([C:3]1[C:4]([NH:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([CH3:14])[CH:9]=2)=[N:5][NH:6][C:2]=1[N:1]=[CH:20][N:21]([CH3:23])[CH3:22])#[N:16]

Participants

4

Reactant 2

HCID 70913Dimethylformamide diethylacetalHCID 15687200HCID 15687200, compound

Product 1

HCID 178425529HCID 178425529, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of 10.71 g (50.22 mmol) of 5-amino-4-cyano-3-(3-methyl-phenylamino)-pyrazole [for preparation see: Arch. Pharm. (Weinheim) 326, 245 (1993)], 9.9 ml (57.8 mmol) of N,N-dimethylformamide diethyl acetal and 150 ml of toluene is heated under reflux for 4 hours. The reaction mixture is then cooled to RT and filtered and the filter residue is washed with toluene and diethyl ether, yielding the title compound; m.p. 260-261° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 4 hours
  3. filtrationfiltered
  4. washthe filter residue is washed with toluene and diethyl ether

Sources & evidence

ORD record
ord-3895825021e94ab880f67efd23b89edc
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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