Benzenamine, 3-chloro-, hydrochloride (1:1) → HCID 178491040, compound

HRID 1602274Notes

Reaction equation

HRID 1602274 reaction equation
[C:1]([C:3]1[C:4]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=2)=[N:5][NH:6][C:7]=1[N:8]=[CH:9][N:10](C)C)#[N:2].Cl.[Cl:23][C:24]1[CH:25]=[C:26]([CH:28]=[CH:29][CH:30]=1)N>CO>[Cl:23][C:24]1[CH:30]=[C:29]([NH:2][C:1]2[N:10]=[CH:9][N:8]=[C:7]3[NH:6][N:5]=[C:4]([NH:13][C:14]4[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH3:21])[CH:15]=4)[C:3]=23)[CH:28]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 67336Benzenamine, 3-chloro-, hydrochloride (1:1)HCID 178491045HCID 178491045, compound

Product 1

HCID 178491040HCID 178491040, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 1.38 g (4.85 mmol) of 4-cyano-5-(dimethylamino-methyleneamino)-3-(3-methoxy-phenylamino)-pyrazole, 0.915 g (5.58 mmol) of 3-chloro-aniline hydrochloride and 20 ml of methanol is heated under reflux for 16 hours. Concentration of the reaction mixture by evaporation in vacuo and recrystallization of the residue from methanol/water yield the title compound; m.p. 202-203° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 16 hours
  3. customConcentration of the reaction mixture by evaporation
  4. customin vacuo and recrystallization of the residue from methanol/water

Sources & evidence

ORD record
ord-8741a685b86e43e8b9df46f2e76f57a2
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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