1,4-Dioxane → HCID 178491040, compound

HRID 1602275Notes

Reaction equation

HRID 1602275 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:8]2[C:13](=[NH:14])[C:12]3[C:15]([NH:18][C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=4)=[N:16][NH:17][C:11]=3[N:10]=[CH:9]2)[CH:5]=[CH:6][CH:7]=1.O1CCOCC1>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:13]2[N:14]=[CH:9][N:10]=[C:11]3[NH:17][N:16]=[C:15]([NH:18][C:19]4[CH:24]=[CH:23][CH:22]=[C:21]([O:25][CH3:26])[CH:20]=4)[C:12]=23)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 312751,4-DioxaneHCID 178491039HCID 178491039, compound

Product 1

HCID 178491040HCID 178491040, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
0 °C

Procedure

A mixture of 0.9 g (2.45 mmol) of 5-(3-chloro-phenyl)-1,5-dihydro-4-imino-3-(3-methoxy-phenylamino)-4H-pyrazolo[3,4-d]pyrimidine, 18 ml of dioxane and 18 ml of water is heated under reflux for 10 hours. Cooling to 0° C., filtering and recrystallization from methanol/water and from methanol yield the title compound; m.p. 203-204° C.

Workup

  1. temperatureis heated
  2. temperatureunder reflux for 10 hours
  3. filtrationfiltering
  4. customrecrystallization from methanol/water

Sources & evidence

ORD record
ord-f9f7524a58f748dfbc968a15a14b39b4
Source dataset
uspto-grants-1999_11
Patent number
US05981533

Reaction notes

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