Acetic Acid → HCID 178478160, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1 g (4.28 mmol) of 5-amino-3-(3-chloro-phenylamino)-4-cyano-pyrazole (Step 49.1), 3.67 g (34.25 mmol) of benzylamine, 0.245 ml (4.28 mmol) of glacial acetic acid and 0.73 ml (19.35 mmol) of formic acid is heated at 200° C. for 20 hours. The reaction mixture is cooled to RT, 30 ml of ice-water and 5 ml of ethanol are added and stirring is carried out for a further 20 minutes. The reaction mixture is then filtered and the filter residue is washed with water. Recrystallization from isopropyl alcohol yields the title compound; m.p. 215-218° C.

Provenance & Evidence