Sodium Hydroxide → HCID 178505490, compound

HRID 1602314Notes

Reaction equation

HRID 1602314 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)=O)=O)=[CH:4][CH:3]=1.[NH:19]([C:23]1[NH:24][C:25]2[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=2[N:27]=1)[C:20]([NH2:22])=[NH:21].[OH-].[Na+]>CO.O>[N:27]1[C:26]2[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=2[NH:24][C:23]=1[N:19]=[C:20]1[NH:22][C:8]2([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=3)[NH:22][C:20](=[N:19][C:23]3[NH:27][C:26]4[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=4[N:24]=3)[NH:21][C:10]2([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[NH:21]1

Participants

6

Reactant 3

HCID 14798Sodium HydroxideHCID 1230724,4'-DifluorobenzilHCID 1785125941-(1H-benzimidazol-2-yl)guanidine

Product 1

HCID 178505490HCID 178505490, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

Following the procedure of Example 1, 4,4'-difluorobenzil (1.0 g, 4.06 mmol) and 2-guanidinobenzimidazole (0.6 g, 3.4 mmol) in methanol (40 mL) was treated with a solution of sodium hydroxide (200 mg, 5 mmol) in 5 mL of water. The title compound was isolated as pale yellow crystals (750 mg, 79% yield). MS (ESI) m/z 561 [M+H]+.

Sources & evidence

ORD record
ord-64ec8efd66394e03be51b258ed78b3e2
Source dataset
uspto-grants-1999_11
Patent number
US05981551

Reaction notes

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