HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1602322Generated: November 1, 2026
Isopropanol → N-[2-(Dimethylamino)ethyl]-2-(methylamino)-1,3-thiazole-4-carboxamide
https://huagongshe.com/reaction/1602322
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Reactant | Ethyl 2-(methylamino)-1,3-thiazole-4-carboxylate | HCID 19611072 | — |
| Product | N-[2-(Dimethylamino)ethyl]-2-(methylamino)-1,3-thiazole-4-carboxamide | HCID 19611059 | 54.8% |
Reaction Steps
In 3.5 g of N,N-dimethylethylenediamine, 2.5 g of 2-(N-methylamino)-4-(ethoxycarbonyl)-1,3-thiazole was dissolved, followed by stirring at 100° C. for 6 hours. The reaction mixture was poured into isopropyl alcohol and the crystals so precipitated were collected by filtration, whereby 1.68 g of the title compound was obtained. Yield: 51.5%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05981557 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-8603b8cd36034db1886ce12d23706f17 |
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| Source note | uspto-grants-1999_11 |
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