Ethyl 1-benzyl-4-(N,N'-di-tert-butyloxycarbonylhydrazino)piperidin-4-ylcarboxylate → HCID 19610927, compound

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Reaction Steps

A solution of ethyl 1-benzyl-4-(N,N'-di-tert-butyloxycarbonylhydrazino)piperidin-4-yl-carboxylate (D26, 14.2 g, 0.030 mol) in methanol (50 ml) was treated with 10% HCl/methanol (100 ml) and heated under reflux for 2 h. The solution was concentrated in vacuo and the residue treated with dry toluene (80 ml) and again concentrated in vacuo to remove any traces of moisture. The residue was trituated with ether and the material filtered off and immediately placed in a vacuum dessicator to give the title compound (D27) (9.48 g, 90%) as a very hygroscopic orange solid.

Provenance & Evidence