HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate → HCID 15663665, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Azabicyclo[2.2.2]oct-3-yl methanesulfonate | HCID 416494 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | HCID 178509299 | HCID 178509299 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 15663665 | HCID 15663665 | — |
Reaction Steps
3-Methanesulphonyloxy-1-azabicylo[2.2.2]octane (D8) (2.0 g, 9.7 mmol) and the sodium salt of 5-aminotetrazole (D15) (2.5 g, 2.0 eq) were dissolved in dry DMF (50 ml) and the reaction carried out as for Example 10. The product (E11) isolated from column chromatography was a white crystalline solid (124 mg, 6.6%), which was recrystallised from ether, m.p. 132-134° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05981545 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-de9bc4b61d6341baa4ed99bafa2397b6 |
| Source note | uspto-grants-1999_11 |