Triethylamine → HCID 9891351, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the diamine 8 (150 mg) in 2.5 mL of CH2Cl2 was added triethylamine (0.057 mL). The solution was cooled to 0° C., and acetic anyhydride (0.019 mL) was added. The reaction was stirred overnight, allowing it to gradually warm to room temperature. The mixture was poured into EtOAc and washed with sat. aq. NaHCO3 and brine, dried (Na2SO4), filtered, and concentrated in vacuo. This material was purified by silica gel chromatography (2.5-5% MeOH/CH2Cl2), taken up in CH2Cl2 and treated with 1 M HCl/ether solution, and concentrated in vacuo. The product hydrochloride 1 was isolated as a white solid.

Provenance & Evidence