HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1602366Generated: November 3, 2026
Dimethylformamide → ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate
https://huagongshe.com/reaction/1602366
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | ethyl 4,6-dichloro-1H-indole-2-carboxylate | HCID 2736407 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | ethyl 4,6-dichloro-3-formyl-1H-indole-2-carboxylate | HCID 2794948 | — |
Reaction Steps
Combine 2-carboethoxy-4,6-dichloroindole (10.0 g, 0.039 mol), and dimethylformamide (4.5 mL, 0.057 mol) in dichloroethane (20 mL). Add phosphoryl chloride (8.9 g, 0.058 mmol). Heat to 80° C. After 18 hours, cool the reaction mixture to ambient temperature and combine with aqueous 1 M sodium acetate solution and stir. After 18 hours, filter, rinse with water, and dry to give 3-formyl-2-carboethoxy-4,6-dichloroindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05981553 |
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| Source dataset | uspto-grants-1999_11 |
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| ORD ID | ord-379fa279703946e1a6e62dac99ab60aa |
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| Source note | uspto-grants-1999_11 |
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