Ethanethiol → HCID 69984381, compound

Participants

Reaction Steps

Reaction of a compound of Example 11 (0.27 g, 0.52 mmol), AlCl3 (0.42 g, 3.12 mmol) and EtSH (0.19 mL, 2.6 mmol) in CH2Cl2 (10 mL) at room temp. for 0.5 h. according to the procedure described in Example 3 provided a 95% of the desired product as a yellow solid: 1H-NMR (300 MHz, CDCl3) δ9.91 (s, 1H), 9.71 (s, 1H), 8.82 (s, 1H), 7.67 (d, J=8.7 Hz, 2H), 7.35 (d, J=2.3 Hz, 1H), 7.26 (d, J=8.8 Hz, 1H), 7.18 (d, J=8.9 Hz, 2H), 6.93 (d, J=8.7 Hz, 2H), 6.86 (dd, J=8.9, 2.3 Hz, 1H), 6.66 (d, J=8.8 hz, 2H), 4.19 (t, J=3.3 Hz, 2H), 3.20 (t, J=3.6 Hz, 2H), 2.32 (s, 3H); IR (thin film) 3299, 1700, 1635 cm-1; MS (FD) 488 (M+) Anal. calcd. for C25H21O4NS2 ; calc'd/found C(66.51/66.88), H (4.34/4.49), N (2.88/2.95).

Provenance & Evidence