反应详情

A mixture of 7-chloro-4-methyl-benzofuran (CAS-number 79444-976; 51.9 g), N-bromosuccinimide (61.4 g), benzoyl peroxide (0.52 g) and carbon tetrachloride (1200 ml) was heated under reflux under the illumination of an 80 W flood lamp for 20 h. The mixture was cooled, and filtered and the filtrate evaporated to dryness. The residue was absorbed onto silica and purified by chromatography on silica using ethyl acetate and hexane (1:20) to give the title compound (39.50 g) as a yellow solid.

1. temperaturewas heated
2. temperatureunder reflux under the illumination of an 80 W flood lamp for 20 h
3. temperatureThe mixture was cooled
4. filtrationfiltered
5. customthe filtrate evaporated to dryness
6. customThe residue was absorbed onto silica
7. custompurified by chromatography on silica