(E)-3-(7-Chloro-benzofuran-4-yl)-acrylonitrile → 3-(2,3-Dihydro-benzofuran-4-yl)-propylamine hydrochloride

Participants

Reaction Steps

A solution of the (E)-3-(7-chloro-benzofuran-4-yl)-acrylonitrile (intermediate 3) (1.0 g) in acetic acid (30 ml) containing 10% palladium on charcoal (50 mg; 50% wet paste) and 5% platinium on charcoal (50 mg) was hydrogenated at 100 psi and 50° for 3 days. The solution was filtered through hyflo and evaporated to dryness and the residue recrystallised from isopropanol to give the title compound as white plates (583 mg).

Provenance & Evidence