Phthalimide → HCID 19611658, compound

Participants

Reaction Steps

Diethylazodicarboxylate (0.35 ml) was added dropwise to a solution of triphenylphosphine (587 mg) and phthalimide (329 mg) in dry THF (10 ml) at 0° under nitrogen. A solution of 3-(7-chloro-benzofuran-4-yl)-propan-1-ol (364 mg) in THF (5 ml) was then added and the mixture allowed to warm to room temperature and stirred for 2 h. The solvent was evaporated and the residue purified by column chromatography, eluting with cyclohexane/ether 3:1 gave the title compound as a colourless solid (521 mg)

Provenance & Evidence