4-Chloro-3-methylphenol → HCID 12661867, compound

Participants

Reaction Steps

A mixture of 4-chloro-3-methylphenol (47 g), bromoacetaldehyde diethyl acetal (45 ml) and potassium hydroxide (33.6 g) in dimethyl sulphoxide (250 ml) was heated at 120° for 2 h. The cooled mixture was partitioned between water (750 ml) and toluene (3×500 ml) and the combined organic extracts washed with brine/water 1:1 (3×300 ml) and dried (Na2SO4). The solvent was evaporated to give the title compound as a pale yellow oil (67.9 g)

Provenance & Evidence