Methyl morpholine oxide → HCID 12661867, compound

Participants

Reaction Steps

A solution of 4-bromomethyl-5-chloro-benzofuran mixture with 6-bromomethyl-5-chloro-benzofuran (30.54 g) in dry acetonitrile (80 ml) was added dropwise to a mixture of N-methylmorpholine-N-oxide (29.14 g) and 4 Å molecular sieves in dry acetonitrile (100 ml) at 100 under nitrogen. The mixture was stirred at room temperature for 5 h, filtered through hyflo and the filtrate evaporated. The residue was triturated under ether (100 ml) and filtered. The filtrate was evaporated and the residue recrystalised from cyciohexane to give the title compound as a pale yellow solid (10.95 g)

Provenance & Evidence