HCID 19611658, compound → HCID 19611661, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2-[3-(7-chloro-benzofuran-4-yl)-propyl]-isoindole-1,3-dione (0.5 g) in ethanolic methylamine (10 ml) was stirred at room temperature for 4 h. The solvent was evaporated and the residue suspended in dry THF (15 ml) and cooled to 0° C. Pyridine (0.27 ml) and acetic anhydride (0.2 ml) were added and the mixture allowed to warm to room temperature and stirred for 18 h. The solvent was evaporated and the residue purified by column chromatography, eluting with dichloromethane/methanol 100:1 gave the title compound as a colourless solid (230 mg) mp 61-62°

Provenance & Evidence