Sodium Carbonate → HCID 19611673, compound

Participants

Reaction Steps

N-Chlorosuccinimide (173 mg) was added to a solution of N-[3-(5-chloro-2,3-dihydro-benzofuran-4-yl)-propyl]-acetamide (0.2 g) in glacial acetic acid (5 ml) at room temperature under nitrogen and the mixture stirred for 64 h. The solution was adusted to pH 9 with sodium carbonate (2N; 10 ml) and extracted with ethyl acetate (3×15 ml). The combined organic extracts were washed with brine (20 ml) and dried (MgSO4). The solvent was evaporated and the residue purified by HPLC, eluting with 50% acetonitrile/water+0.1% TFA gave the title compound as a colourless gum (97 mg)

Provenance & Evidence