HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → N-[3-(7-Fluoro-2,3-dihydro-benzofuran-4-yl)-propyl]-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-(7-Fluoro-2,3-dihydro-benzofuran-4-yl)-propylamine | HCID 19611649 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | N-[3-(7-Fluoro-2,3-dihydro-benzofuran-4-yl)-propyl]-acetamide | HCID 19611636 | — |
Reaction Steps
Acetic anhydride (0.18 ml) was added dropwise to a solution of 3-(7-fluoro-2,3-dihydro-benzofuran-4-yl)-propylamine (256 mg) in, dry THF (10 ml) containing pyridine (0.21 ml) at 0° under nitrogen and the solution stirred overnight at room temperature. The solution was evaporated and the residue purified by column chromatography. Eluting with dichloromethane:methanol: (50:1) gave the title compound as a colouriess oil (133 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05981572 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-1fd8d614bf8e4809af75d33b72ce7758 |
| Source note | uspto-grants-1999_11 |