HCID 54522360, compound → HCID 19611380, compound

Participants

Reaction Steps

3-[2-(4-tert-Butyl-2-thiazolyl)vinyl]benzoic acid (1.20 g, 4.18 mmol) was dissolved in tetrahydrofuran (24 ml), 10% palladium-carbon powder (0.2 g) was added to the solution, and the mixture was stirred at room temperature for 3 hours in an atmosphere of hydrogen. The reaction solution was filtered and the resulting filtrate was concentrated under reduced pressure. By crystallizing the resulting residue from diethyl ether-hexane, 3-[2-(4-tert-butyl-thiazolyl)ethyl]benzoic acid (1.12 g, 93%) was obtained.

Provenance & Evidence