HCID 54318654, compound → HCID 19611331, compound

Participants

Reaction Steps

Ethyl 2-[3-[(4-tert-butyl-2-thiazolyl)methoxy]-5-(4-nitrobenzyloxycarbonylamino)benzoylamino]-4-[3-(4-chlorophenylsulfonyl)propyl]phenoxyacetate (0.50 g, 0.57 mmol) was dissolved in a mixed solution of ethanol (10 ml) and tetrahydrofuran (10 ml), 10% palladium-carbon (0.10 g) was added to the solution, and the mixture was stirred at room temperature for 3 hours in an atmosphere of hydrogen. The reaction solution was filtered and the resulting filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent=acetone:chloroform=3:100) and crystallized from acetonitrile to give ethyl 2-[3-amino-5-[(4-tert-butyl-2-thiazolyl)methoxy]benzoylamino]-4-[3-(4- chlorophenylsulfonyl)propyl]phenoxyacetate (0.17 g, 0.24 mmol, 43%) as light yellow crystals. Its structure is shown in Table 30.

Provenance & Evidence