Sodium Hydroxide → 5-Hydroxy-2-methoxypyridine

HRID 1602543Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1602543
C([O:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1)(=O)C.[OH-].[Na+]>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:11][CH3:12])=[N:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 224515665-Acetoxy-2-methoxypyridine

Produkt 1

HCID 116223355-Hydroxy-2-methoxypyridine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of the 5-acetoxy-2-methoxypyridine(600 mg, 3.59 mmol) in MeOH(10 mL) was added 1M aq. NaOH(10 mL, 10 mmol). After stirring at r.t. for 30 min, volatile solvent was removed in vacuo, acidified with HOAc and extracted with CHCl3(3×). The combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and evaporated to give the title compoud as a brown oil(240 mg, solidified on standing).

Aufarbeitung

  1. customvolatile solvent was removed in vacuo
  2. extractionextracted with CHCl3(3×)
  3. washThe combined CHCl3 extracts were washed with H2O, dried(anhydrous MgSO4) and
  4. customevaporated
  5. customto give the title compoud as a brown oil(240 mg, solidified on standing)

Quellen und Nachweise

ORD-Eintrag
ord-d918e9dc07de41aa88128b74ba1a84b8
Quelldatensatz
uspto-grants-1999_11
Patentnummer
US05981576

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