関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Cyclopropylethanol | HCID 79104 | — |
| 反応物 | 3-Diazofuran-2,4-dione | HCID 15439113 | — |
| 触媒 | Rhodium acetate | HCID 168478 | — |
| 生成物 | 3-(1-cyclopropylethoxy)-4-hydroxy-2(5H)-furanone | HCID 70106454 | — |
反応手順
To the mixture of 3-diazo-2,4-(3H, 5H)-furandione (300 mg, 2.38 mmol; Example 207, Step 1) and α-methylcyclopropanemethanol (2.0 mL) was added rhodium acetate (30 mg). The mixture was heated at 130° C. for a period of 18 h. The excess of alcohol was evaporated under reduced pressure and the resulting crude mixture was purified by flash chromatography (10% to 20% MeOH in CH2Cl2) to provide 50 mg of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05981576 |
|---|
| 出典データセット | uspto-grants-1999_11 |
|---|
| ORD ID | ord-1ad36e16705846fbb2bf4c5139b3d46a |
|---|
| 出典メモ | uspto-grants-1999_11 |
|---|
