HCID 86754790, compound → HCID 70107872, compound

Participants

Reaction Steps

384 mg of methyl (3RS,4RS)-3-(tert-butoxycarbonyl)-4-hydroxy-4-[N-[(1R,2R)-1-methyl-2-(3, 4-methylenedioxyphenyl)-3-{5-(phenylcarbamoyl)-2-furyl}propyl]-N-{(E)-3-phenyl-2-propenyl}carbamoyl]butanoate was dissolved in 15 ml of acetonitrile and stirred together with 219 mg of tetrapropylammonium perruthenate at room temperature for 1 hour. The solvent was distilled off under reduced pressure, and the residue was preliminarily purified by silica gel short column chromatography [chloroform→methanol] and the purified again by silica gel column chromatography [hexane/ethyl acetate=2/1→3/2] to give 285 mg (yield: 74%) of the title compound as a colorless oily substance.

Provenance & Evidence