HCID 70109999, compound → HCID 70107202, compound

HRID 1602568Notes

Reaction equation

O=C1OCC(C([O-])=O)C1.[C:10]([O:14][C:15]([C:17](=[C:22]([OH:62])[C:23](=[O:61])[N:24]([C@H:34]([CH3:60])[C@@H:35]([C:51]1[CH:56]=[CH:55][C:54]2[O:57][CH2:58][O:59][C:53]=2[CH:52]=1)[CH2:36][C:37]1[O:38][C:39]([C:42](=[O:50])[NH:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)=[CH:40][CH:41]=1)[CH2:25]/[CH:26]=[CH:27]/[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)[CH2:18][C:19]([OH:21])=[O:20])=[O:16])(C)([CH3:12])[CH3:11]>>[CH:10]([O:14][C:15]([C:17](=[C:22]([OH:62])[C:23](=[O:61])[N:24]([CH:34]([CH3:60])[CH:35]([C:51]1[CH:56]=[CH:55][C:54]2[O:57][CH2:58][O:59][C:53]=2[CH:52]=1)[CH2:36][C:37]1[O:38][C:39]([C:42](=[O:50])[NH:43][C:44]2[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=2)=[CH:40][CH:41]=1)[CH2:25]/[CH:26]=[CH:27]/[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1)[CH2:18][C:19]([OH:21])=[O:20])=[O:16])([CH3:12])[CH3:11]

Participants

Reactant 2

HCID 70109999HCID 70109999, compound

HCID 131721444HCID 131721444, compound

Product 1

HCID 70107202HCID 70107202, compoundYield 17%

Procedure

56 mg of isopropyl (2RS,3RS)-2-[N-(1RS,2RS)-1-methyl-2-(3,4-methylenedioxyphenyl)-3-{5-(phenylcarbamoyl)-2-furyl}propyl]-N-{(E)-3-phenyl-2-propenyl}carbamoyl]-5-oxotetrahydrofuran-3-carboxylate was subjected to the same reactions as in Example 1(2) to (4) to give 10 mg (yield: 17%) of the title compound.

Sources & evidence

ORD record: ord-3c11ad2807324bc89f60ddb3fd90ab05
Source dataset: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05981573

Reaction notes

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