HCID 70108212, compound → HCID 70110078, compound

HRID 1602579Notes

Reaction equation

HRID 1602579 reaction equation
[C:1]1(/[CH:7]=[CH:8]/[CH2:9][NH:10][C@H:11]([CH3:37])[C@@H:12]([C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=2)[CH2:13][C:14]2[O:15][C:16]([C:19](=[O:27])[NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:17][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:38][C@H:39]([CH3:61])[C@H:40]([C:52]1[CH:57]=[CH:56][C:55]([N+:58]([O-:60])=[O:59])=[CH:54][CH:53]=1)[CH2:41][C:42]1[O:46][C:45]([C:47]([O:49][CH2:50][CH3:51])=[O:48])=[CH:44][CH:43]=1>>[C:1]1(/[CH:7]=[CH:8]/[CH2:9][NH:10][C@@H:11]([CH3:37])[C@H:12]([C:28]2[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=2)[CH2:13][C:14]2[O:15][C:16]([C:19](=[O:27])[NH:20][C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[CH:17][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:14]([O:38][C@H:39]([CH3:61])[C@H:40]([C:52]1[CH:53]=[CH:54][C:55]([N+:58]([O-:60])=[O:59])=[CH:56][CH:57]=1)[CH2:41][C:42]1[O:46][C:45]([C:47]([O:49][CH2:50][CH3:51])=[O:48])=[CH:44][CH:43]=1)(=[O:15])[CH3:13]

Participants

4

Reactant 2

HCID 70108212HCID 70108212, compoundHCID 70108879HCID 70108879, compound

Product 2

HCID 70110078HCID 70110078, compoundHCID 70277500HCID 70277500, compound

Procedure

N-{(E)-3-Phenyl-2-propenyl}-[(1S,2S)-1-methyl-2-(4-nitrophenyl)-3-{5-(phenylcarbamoyl)-2-furyl}propyl]amine was prepared in the same manner as in (2) from ethyl 5-{(2S,3R)-3-hydroxy-2-(4-nitrophenyl)butyl}-2-furancarboxylate obtained by alkali hydrolysis of ethyl 5-{(2S,3R)-3-acetoxy-2-(4-nitrophenyl)butyl}-2-furancarboxylate prepared in (1) as described above.

Sources & evidence

ORD record
ord-687845f5ef1543a2bd407524e8021564
Source dataset
uspto-grants-1999_11
Patent number
US05981573

Reaction notes

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