HCID 10516874, compound → HCID 10732558, compound

HRID 1602596Notes

Reaction equation

HRID 1602596 reaction equation
[C:1]([C@H:3]1[CH2:7][O:6][C:5]([CH3:9])([CH3:8])[O:4]1)#[CH:2].[CH2:10]([O:12][C:13]([C:15]1[S:19][C:18](Br)=[C:17]([CH3:21])[CH:16]=1)=[O:14])[CH3:11].C(OC(C1SC(C#C[C@H]2COC(C)(C)O2)=CC=1)=O)C>>[CH2:10]([O:12][C:13]([C:15]1[S:19][C:18]([C:2]#[C:1][C@H:3]2[CH2:7][O:6][C:5]([CH3:9])([CH3:8])[O:4]2)=[C:17]([CH3:21])[CH:16]=1)=[O:14])[CH3:11]

Participants

4

Reactant 3

HCID 10516874HCID 10516874, compoundHCID 110188661,3-Dioxolane, 4-ethynyl-2,2-dimethyl-, (4S)- (9CI)HCID 11644483HCID 11644483, compound

Product 1

HCID 10732558HCID 10732558, compoundYield 67%

Procedure

Starting with 4(S)-Ethynyl-2,2-dimethyl-[1,3]dioxolane and 2-Bromo-3-methyl-thiophene-5-carboxylic acid ethyl ester, prepared according to M. Nemec, Collection Czechoslov. Chem. Commun., compound (31) was prepared in 67% yield according to the general procedure described for compound (1).

Workup

  1. customprepared
  2. customNemec, Collection Czechoslov

Sources & evidence

ORD record
ord-1056946683dd42c783c103b40d17a391
Source dataset
uspto-grants-1999_11
Patent number
US05981748

Reaction notes

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