HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl (2-Oxo-3-(2-([1,8]naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-acetate → Ethyl (2-Oxo-3-(2-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl (2-Oxo-3-(2-([1,8]naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)-acetate | HCID 53717087 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl (2-Oxo-3-(2-(5,6,7,8-tetrahydro-[1,8]-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)acetate | HCID 54307208 | — |
Reaction Steps
A mixture of 2-6 (0.87 g, 2.6 mmol), 10% Pd/C (0.5 g), and CH3OH (25 mL) was stirred under a hydrogen atmosphere (1 atm) for 2 hr. The catalyst was then removed by filtration through a celite pad followed by concentration of the filtrate. Flash chromatogrphy (silica, EtOAc→5% CH3OH/EtOAc) gave 2-7 as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05981546 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-8d02ff28c8e7435e93704827d432d5f6 |
| Source note | uspto-grants-1999_11 |