Sodium Hydroxide → HCID 86754786, compound

HRID 1602640Notes

Reaction equation

HRID 1602640 reaction equation
C([O:3][C:4](=[O:13])[CH2:5][C@@H:6]([C:11]#[CH:12])[NH:7][C:8](=[O:10])[CH3:9])C.[OH-].[Na+]>CCO>[C:8]([NH:7][C@H:6]([C:11]#[CH:12])[CH2:5][C:4]([OH:13])=[O:3])(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86754785HCID 86754785, compound

Product 1

HCID 86754786HCID 86754786, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 11-13 (70 mg, 0.1589 mmol) in EtOH (1 mL) was added 1N NaOH (0.175 ml, 0.164 mmol). After stirring for 1 h, the solvents were evaporated and the residue was chromatographed (silica gel, 25:10:1:1 to 15:10:1:1 ethyl acetate/EtOH/water/NH4OH to give 11-14 as a colorless foam.

Workup

  1. customthe solvents were evaporated
  2. customthe residue was chromatographed (silica gel, 25:10:1:1 to 15:10:1:1 ethyl acetate/EtOH/water/NH4OH

Sources & evidence

ORD record
ord-e5c4101ea5a440428c15646330bcf35c
Source dataset
uspto-grants-1999_11
Patent number
US05981546

Reaction notes

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