Sodium triacetoxyborohydride → HCID 86754785, compound

Participants

Reaction Steps

To a solution of 13-11 (450 mg, 1.39 mmol) and 5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carbaldehyde (225 mg, 1.39 mmol) in dichloroethane at 0° C. was added Na(OAc)3BH. After 1.5 h the reaction was quenched with sat. NaHCO3, diluted with EtOAc, washed with sat. NaHCO3, brine and dried over MgSO4. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:20:10 chloroform/ethyl acetate/MeOH to give 13-12 as a colorless foam.

Provenance & Evidence