Toluene → HCID 19607260, compound

HRID 1602730Notes

Reaction equation

HRID 1602730 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH3:8])[NH:3]1.C1(C)C=CC=CC=1.[S:16]1[CH2:18][CH2:17]1>>[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH:4]([CH3:8])[N:3]1[CH2:18][CH2:17][SH:16]

Participants

4

Reactant 3

HCID 1140TolueneHCID 9865ThiiraneHCID 68843Nanofin

Product 1

HCID 19607260HCID 19607260, compound

Procedure

In a 500 ml three-necked flask 113.2 g(1 mol) of 2,6-dimethylpiperidine in 250 mol toluene was heated at 90° C. Then 60.12 g (1 mol) thiirane is added to the resulting reaction mixture dropwise and the reaction mixture is heated for 5 hours under reflux. The reaction mixture is concentrated in vacuum with a rotary evaporator and is fractionally distilled using a Vigreux column. The yield amounts to 60.55 g of the named compound(35%).

Workup

  1. temperaturethe reaction mixture is heated for 5 hours
  2. temperatureunder reflux
  3. concentrationThe reaction mixture is concentrated in vacuum with a rotary evaporator
  4. distillationis fractionally distilled

Sources & evidence

ORD record
ord-663d6c878c7943aeb80fdaaaf2b0b314
Source dataset
uspto-grants-1999_11
Patent number
US05985253

Reaction notes

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