Ethanolamine → N-(2-mercaptoethyl)-N'-(2-hydroxyethyl)succinamide

HRID 1602732Notes

Reaction equation

HRID 1602732 reaction equation
[SH:1][CH2:2][CH2:3][NH:4][C:5](=[O:11])[CH2:6][CH2:7][C:8]([OH:10])=O.[CH2:12]([CH2:14][NH2:15])[OH:13]>CO>[SH:1][CH2:2][CH2:3][NH:4][C:5](=[O:11])[CH2:6][CH2:7][C:8]([NH:15][CH2:14][CH2:12][OH:13])=[O:10]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 224508284-Oxo-4-[(2-sulfanylethyl)amino]butanoic acid

Product 1

HCID 15293891N-(2-mercaptoethyl)-N'-(2-hydroxyethyl)succinamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 4.4 g (23 mmol) of methyl ester of N-(2-mercaptoethyl)succinamic acid obtained in Example 1a) in 20 cm3 of methanol, and 1.68 g (27 mmol) of ethanolamine was stirred for 5 hours at 60° C. under argon atmosphere.

Sources & evidence

ORD record
ord-5217eea9256345998d2a6887ff122841
Source dataset
uspto-grants-1999_11
Patent number
US05985257

Reaction notes

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