Ammonia → HCID 15293892, compound

HRID 1602733Notes

Reaction equation

HRID 1602733 reaction equation
[SH:1][CH2:2][CH2:3][NH:4][C:5](=[O:10])[CH2:6][C:7](O)=[O:8].[NH3:11]>>[SH:1][CH2:2][CH2:3][NH:4][C:5](=[O:10])[CH2:6][C:7]([NH2:11])=[O:8]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 19607279HCID 19607279, compound

Product 1

HCID 15293892HCID 15293892, compound

Procedure

31 g of methyl ester of N-(2-mercapto-ethyl)malonamic acid obtained in Example 3a) were added to 220 cm3 of aqueous 20% solution of aqueous ammonia, with stirring, while the temperature was kept below or equal to 30° C. Stirring was continued for 1 hour at ambient temperature. A slight cloudiness was removed by filtration on sintered glass. The filtrate was evaporated to dryness at reduced pressure. The solid obtained was recrystallized from ethyl acetate. After filtering and drying in vacuum at 50° C., 27 g of N-(2-mercaptoethyl)malonamide were obtained in the form of a white solid with a melting point of 100° C.

Workup

  1. customwas kept below or equal to 30° C
  2. stirringStirring
  3. customA slight cloudiness was removed by filtration on sintered glass
  4. customThe filtrate was evaporated to dryness at reduced pressure
  5. customThe solid obtained
  6. customwas recrystallized from ethyl acetate
  7. filtrationAfter filtering
  8. customdrying in vacuum at 50° C.

Sources & evidence

ORD record
ord-e30492eefc3540788e783234e249fecf
Source dataset
uspto-grants-1999_11
Patent number
US05985257

Reaction notes

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