Sodium Azide → HCID 18394851, compound

Participants

Reaction Conditions

Reaction Steps

2'-O-Benzyl-5'-bromo-5'-deoxyuridine (4.3 g) was dissolved in DMF (86 ml) and sodium azide (7 g) added. The mixture was stirred and heated at 60° C. for 45 mins. After cooling and decanting from unreacted sodium azide the DMF was evaporated to dryness. The residue was dissolved in ethyl acetate and washed twice with water, dried and evaporated to dryness. The residue was chromatographed on Merck silica gel (Art. 9385). Elution with 10% methanol in toluene gave 1.5 g of pure 5'-azido-2'-O-benzyl-5'-deoxyuridine.

Provenance & Evidence