Dibenzyl 2-((bis(benzyloxy)phosphoryl)methyl)pentanedioate → 2-(Phosphonomethyl)pentanedioic acid

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Reaction Steps

The benzyl pentanedioate 2(2.9 g, 4.9 mmol) was added to a mixture of 20 ml of methanol containing 0.29 g (6 mol %) of 10% Pd/C. This mixture was hydrogenated on a Parr hydrogenator at 40 psi for 24 hours, filtered and evaporated to give 3(1.0 g, 90%) as a clear slightly golden viscous oil.

Provenance & Evidence