HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Donepezil Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | — |
Reaction Steps
0.3 g of Donepezil was dissolved in 1.5 ml of methanol, followed by addition of 0.97 ml of 10%-hydrochloric acid in methanol mixture. Filtration of the separated crystal and drying under atmosphere afforded 0.2 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05985864 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-7c69ae22a9274d7d9642d307137cbc8c |
| Source note | uspto-grants-1999_11 |