Hydrochloric Acid → Donepezil Hydrochloride

Participants

Reaction Steps

308 g of Donepezil was dissolved in 700 ml of ethanol. Under stirring, 230 ml of 10%-hydrogen chloride in ethanol solution and 5000 ml of diethyl ether were added successively. Filtration of the crystals and drying at 50° C. for 1 hour, then at 60° C. for 30 minutes, then at 85° C. for 12 hours afforded 269 g of the title compound.

Provenance & Evidence