HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Donepezil Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | 95.9% |
Reaction Steps
59 g of Donepezil was dissolved in 590 ml of ethanol. Under cooling in a bath containing ice water, 17.8 g of concentrated hydrochloric acid and 885 ml of diisopropyl ether were added successively. After stirring over night at room temperature, filtration of the crystals and drying at 55° C. for 22 hours afforded 62 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05985864 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-3c18670df8b84312b23c037589695772 |
| Source note | uspto-grants-1999_11 |