Hydrochloric Acid → Donepezil Hydrochloride

Participants

Reaction Conditions

Reaction Steps

1.0 g of Donepezil was dissolved in 9 ml of acetonitrile under heating at 40° C. The solution was cooled in an iced water bath. After cooling for 2 minutes, 0.31 g of concentrated hydrochloric acid in 1 ml of acetonitrile was added hereinto. It continued stirring for 50 minutes in an iced water bath. Filtration of the separated crystals followed by drying afforded 0.63 g of the title compound. (water content: 5.59%)

Provenance & Evidence