Hydrochloric Acid → Donepezil Hydrochloride

Participants

Reaction Conditions

Reaction Steps

4.0 g of Donepezil was dissolved in 20 ml of methanol under heating at 40° C. The solution was cooled in an iced water bath. Hydrogen chloride gas was blown hereinto at 3° C. inner temperature, until the atmosphere turns acidic. It continued stirring for 20 minutes in an iced water bath. Filtration of the separated crystals followed by drying afforded 3.40 g of the title compound. (water content: 5.19%)

Provenance & Evidence