Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | tert-Butyl methyl ether | HCID 15413 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | 98.5% |
Reaction Steps
1.0 g of Donepezil was dissolved in 4 ml of ethanol under heating at 40° C. The solution was cooled in an iced water bath. After cooling for 4 minutes, 0.31 g of concentrated hydrochloric acid in 1 ml of ethanol was added hereinto. After 3 minutes, 30 ml of TBME was added hereinto. It continued stirring for 50 minutes in an iced water bath. Filtration of the separated crystals followed by drying afforded 1.08 g of the title compound. (water content: 1.78%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05985864 |
|---|
| Source dataset | uspto-grants-1999_11 |
|---|
| ORD ID | ord-5ca3c7f0c0964e3cb422f5b8d7d13aff |
|---|
| Source note | uspto-grants-1999_11 |
|---|
