Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | 98.5% |
Reaction Steps
1.0 g of Donepezil was dissolved in 9 ml of ethyl acetate under heating at 40° C. The solution was cooled in an iced water bath. 0.31 g of Concentrated hydrochloric acid in 1 ml of ethyl acetate was added hereinto. It continued stirring for 30 minutes at room temperature. Filtration of the separated crystals followed by drying afforded 1.08 g of the title compound. (water content: 0.21%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05985864 |
|---|
| Source dataset | uspto-grants-1999_11 |
|---|
| ORD ID | ord-dc861f5d314c4f05a0f5ebb96684c19d |
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| Source note | uspto-grants-1999_11 |
|---|
