Hydrochloric Acid → Donepezil Hydrochloride

Participants

Reaction Steps

1.0 g of Donepezil was almost dissolved in 9 ml of acetonitrile at 21° C. The solution was cooled in an iced water bath. 0.31 g of Concentrated hydrochloric acid in 1 ml of acetonitrile was added hereinto. The solution became homogeneous. It continued stirring over night at room temperature. Filtration of the separated crystals followed by drying afforded 1.05 g of the title compound. (water content: 0.05%)

Provenance & Evidence