Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | 98.5% |
Reaction Steps
1.0 g of Donepezil was dissolved in 4 ml of DMF under heating at 40° C. The solution was cooled in an iced water bath. 0.31 g of Concentrated hydrochloric acid in 1 ml of DMF was added hereinto. It continued stirring for 30 minutes in an iced water bath. Filtration of the separated crystals followed by drying afforded 1.08 g of the title compound. (water content: 0.72%)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05985864 |
|---|
| Source dataset | uspto-grants-1999_11 |
|---|
| ORD ID | ord-abf639e3eb2642d8906023efd0d6e40e |
|---|
| Source note | uspto-grants-1999_11 |
|---|
