Hydrochloric Acid → Donepezil Hydrochloride

Participants

Reaction Conditions

Reaction Steps

2.0 g of Donepezil was dissolved in 20 ml of ethanol under heating at 40° C. The solution was cooled to room temperature in an iced water bath. Hydrogen chloride gas was blown hereinto at 24° C. inner temperature, until the atmosphere turns acidic. After stirring for 10 minutes, 50 ml of TBME was added. It continued stirring over night at room temperature. Filtration of the separated crystals followed by drying afforded 2.11 g of the title compound. (water content: 0.07%)

Provenance & Evidence