Hydrochloric Acid → Donepezil Hydrochloride

Participants

Reaction Conditions

Reaction Steps

10.0 g of Donepezil was dissolved in 100 ml of ethanol under heating at 40° C. The solution was cooled to room temperature. 3.01 g of Concentrated hydrochloric acid was added hereinto at 20° C. inner temperature. The solution was set in an iced water bath. After 9 minutes stirring, 150 ml of isopropyl ether was added hereinto at 3° C. inner temperature. It continued stirring for 300 minutes in an iced water bath. Filtration of the separated crystals followed by drying afforded the title compound.

Provenance & Evidence