Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | — |
Reaction Steps
10.0 g of Donepezil was dissolved in 100 ml of ethanol under heating at 40° C. The solution was cooled to room temperature. 3.01 g of Concentrated hydrochloric acid was added hereinto at 20° C. inner temperature. After 9 minutes stirring, 150 ml of isopropyl ether was added hereinto at 20° C. inner temperature. It continued stirring for 120 minutes at room temperature. Filtration of the separated crystals followed by drying afforded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05985864 |
|---|
| Source dataset | uspto-grants-1999_11 |
|---|
| ORD ID | ord-047a195641944e5896346053bfaa520f |
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| Source note | uspto-grants-1999_11 |
|---|
