HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Amino-2-propanol → HCID 19608266, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Amino-2-propanol | HCID 4 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 6-hydroxy-1,3-dioxaindane-5-carboxylic acid | HCID 15884629 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 19608266 | HCID 19608266 | 67% |
Reaction Steps
4,5-Methylenedioxysalicylic acid was activated by carbonyldiimidazole in methylene chloride and combined with 1-amino-2-propanol in essentially an identical manner as for Example 1 above. An acidic quench and subsequent purification by flash chromatography (SiO2) using (1:1) hexane-ethyl acetate gave 1-(2-hydroxy-4,5-methylenedioxybenzamido)-2-propanol as a waxy white solid in 67% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05985871 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-5bf31cb299aa4f6589dd4ada435f2096 |
| Source note | uspto-grants-1999_11 |